A rare case of NXP-2 positive dermatomyositis
##plugins.themes.bootstrap3.article.main##
##plugins.themes.bootstrap3.article.sidebar##
Abstract
Dermatomyositis is an idiopathic inflammatory myopathy with variable cutaneous manifestations. Several autoantibodies each with distinct clinical phenotypes are associated with the disease. Here we present the case of a 36-year-old Laotian woman with hypothyroidism who presented with severe proximal and distal muscle weakness, dysphagia, diffuse rash, and anasarca that was diagnosed with NXP-2 (nuclear matrix protein 2) antibody positive dermatomyositis. The patients hospitalization was complicated by disease resistant to conventional therapy.
##plugins.themes.bootstrap3.article.details##
rheumatology, hypothyroidism, dermatomyositis, NXP-2
2. Hu T, Vinik O. Dermatomyositis and malignancy. Can Fam Physician 2019; 65(6):409-411.
3. Myositis Antibodies. Myositis Support and Understanding, [https://understandingmyositis.org/myositis-antibody-testing available at 03.28.2021]
4. Albayda J, Pinal-Fernandez I, Huang W, et al. Antinuclear Matrix Protein 2 autoantibodies and edema, muscle disease, and malignancy risk in dermatomyositis patients. Arthritis Care Res (Hoboken) 2017; 69(11):1771-1776.
5. Espada G, Maldonado Cocco JA, Fertig N, Oddis CV. Clinical and serologic characterization of an Argentine pediatric myositis cohort: identification of a novel autoantibody (anti-MJ) to a 142-kDa protein. J Rheumatol 2009; 36(11):2547-2551.
6. Rogers A, Chung L, Li S, Casciola-Rosen L, Fiorentino DF. Cutaneous and systemic findings associated with Nuclear Matrix Protein 2 antibodies in adult dermatomyositis patients. Arthritis Care Res (Hoboken) 2017; 69(12):1909-1914.
7. Dermatomyositis. NORD (National Organization for Rare Disorders), [https://rarediseases.org/rare-diseases/dermatomyositis Available at 03.28.2021]
8. Ruhlman D, Otten C, Collela C. Dermatomyositis. J Nurse Pract 2014; 10(9):674-681.
9. Miller ML. Initial treatment of dermatomyositis and polymyositis in adults. In UpToDate, Ramirez Curtis, M (Ed), UpToDate, Waltham, MA, 2021.
10. Miller ML. Treatment of recurrent and resistant dermatomyositis and polymyositis in adults. In UpToDate, Ramirez Curtis, M (Ed), UpToDate, Waltham, MA, 2021.
11. Paik JJ, Casciola-Rosen L, Shin JY, et al. Study of tofacitinib in refractory dermatomyositis: An open label pilot study of 10 patients. Arthritis Rheumatol 2020; Epub ahead of print. PMID: 33258553. doi: 10.1002/art.41602.
12. Cordeiro AC, Isenberg DA. Treatment of inflammatory myopathies. Postgrad Med J 2006; 82(969):417-424.
Archive of Clinical Cases is protected by copyright and may be used in accordance with copyright and other applicable laws. Content available at www.clinicalcases.eu and our digital applications is intended for personal noncommercial use.
Authors who submit a manuscript for publication in Archive of Clinical Cases agree to the following terms: a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) only after the final version of the manuscript was accepted and published, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). d. It is compulsory that before submission authors ensure that their work was not published in any other medical journals or pending acceptance for publication and that "Archives of Clinical Cases" is the only beneficiary at that moment if their work/case will be accepted by us.
Guidelines for linking to www.clinicalcases.eu a. The main purpose of the site linking to the Archive of Clinical Casess site should be educational. b. Links should be made to the Archive of Clinical Casess home page (www.clinicalcases.eu) or to the articles abstract. c. It is forbidden to use the Archive of Clinical Casess cover by outside organizations unless permission has been granted in advance, notifying our Secretary. d. Material owned by the Archive of Clinical Cases (including the name, logo, cover, and text) may not be used in any manner that may induce the idea or suggest that the Archive of Clinical Cases is in some way recommending a specific company, product or service. e. You must not use or allow others to access or use, all or any part of our Site or the contents and/or applications on it for commercial purposes without our permission. To seek permission to do anything prohibited by or not contained in these TERMS, or which requires our prior consent or agreement, you can contact us.