Fatal neonatal persistent pulmonary hypertension caused by vegetations of infective endocarditis – case report and review of the literature
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http://orcid.org/0000-0002-5187-9938
Ecaterina Iftime
Daniela Claudia Scripcaru
Andrei Petrariu
Gabriela Ildiko Zonda
Maria Stamatin
Luminița Păduraru
Abstract
Neonatal infective endocarditis is a rare condition and usually pertains to a specific class of immunologically depressed preterm infants, with a long history of invasive procedures in the Neonatal Intensive Care Unit. We report the case of an aggressive and fatal neonatal infective endocarditis in a full-term infant, who developed massive endocardial vegetations on the tricuspid valve, leading to persistent pulmonary hypertension of the newborn, unresponsive to nitric oxide ventilation. Post-mortem cardiac cultures were positive with Serratia marcescens, an unusual germ for an early-onset infection, which was absent in blood cultures.
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neonatal infective endocarditis, persistent pulmonary hypertension of the newborn, endocardial vegetations, Serratia marcescens
2. Day MD, Gauvreau K, Shulman S, Newburger JW. Characteristics of children hospitalized with infective endocarditis. Circulation 2009; 119(6):865-870.
3. Marom D, Levy I, Gutwein O, et al. Healthcare-associated versus community-associated infective endocarditis in children. Pediatr Infect Dis J 2011; 30(7):585-588.
4. Saiman L, Prince A, Gersony WM. Pediatric infective endocarditis in the modern era. J Pediatr 1993; 122:847-853.
5. Ware AL, Tani LY, Weng HY, et al. Resource utilization and outcomes of infective endocarditis in children. J Pediatr 2014; 165:807-812.
6. Baltimore RS, Gewitz M, Baddour, LM, et al. Infective Endocarditis in Childhood: 2015 Update. A scientific statement from the American Heart Association. Circulation 2015; 132:1487-1515.
7. Daher AH, Berkowitz FE. Infective endocarditis in neonates. Clin Pediatr (Phila) 1995; 34:198-206.
8. Garcia-Teresa MA, Casado-Flores J, Delgado Domingues MA, et al. Infectious complications of percutaneous central venous catheterization in pediatric patients: a Spanish multicenter study. Intensive Care Med 2007; 33(3):466-476.
9. Rastogi A, Luken JA, Pildes RS, et al. Endocarditis in neonatal intensive care unit. Pediatr Cardiol 1993; 14:183-186.
10. Ferrieri P, Gewitz MH, Gerber MA, et al. Unique features of infective endocarditis in childhood. Circulation 2002; 105:2115-2127.
11. Johnson JA, Boyce TG, Cetta F, et al. Infective endocarditis in the pediatric patient: a 60-year single-institution review. Mayo Clin Proc 2012; 87(7):629-635.
12. Milazzo AS Jr, Li JS. Bacterial endocarditis in infants and children. Pediatr Infect Dis J 2001; 20:799-801.
13. Toganel R. Infective endocarditis in children — New approach in antimicrobial prophylaxis. J Interdisciplinary Med 2016; 1(1):9-11.
14. Azhar A. Successful management of fungal pericarditis and endocarditis in a neonate: A case report. J Saudi Heart Assoc 2012; 24:195–199.
15. Tissieres P, Gervaix A, Beghetti M, Jaeggi ET. Value and limitations of the von Reyn, Duke, and Modified Duke Criteria for the diagnosis of infective endocarditis in children. Pediatrics 2003; 112(6 Pt 1):e467.
16. Nadroo AM, Al She Wear A; Al Sowailem AM, Al Jubair F. Infective endocarditis in a neonate. Annals Saudi Med 1997; 17(3):347-349.
17. Opie GF, Fraser SH, Drew JH, Drew S. Bacterial endocarditis in neonatal intensive care. J Paediatr Child Health 1999; 35:545–548.
18. Mecrow IK, Ladusans EJ. Infective endocarditis in newborn infants with structurally normal hearts. Acta Paediatr 1994; 83:35-39.
19. Vaideeswar P, Sivaraman A, Deshpande JR. Non-bacterial thrombotic endocarditis in a neonate. Indian Pediatr 1998; 35:62-63.
20. Morrow WR, Haas JE, Benjamin DR. Nonbacterial endocardial thrombosis in neonates: Relationship to persistent fetal circulation. J Pediatr 1982; 100:117-122.
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