The importance of annual screening of thyroid function among the pediatric patients with Down syndrome - case report

Madalina-Ionela Chiriac, Cristina Preda, Laura-Mihaela Trandafir

Abstract


Down syndrome (21 trisomy) is a genetic disorder caused by the presence of an extra chromosome. Thyroid disorders occurs frequently (8-18%) among pediatric patients with Down syndrome. To prevent them, it is necessary to perform a range of investigations that are part of annual screening of each person diagnosed with Down syndrome. In this article we report the association of Down syndrome and an acquired severe hypothyroidism due to autoimmune thyroiditis in a 7 years-old female patient.

Keywords


Down syndrome, hypothyroidism, child, autoimmunity

Full Text:

PDF

References


Kusters MAA, Verstegen RHJ et al: Intrinsic defect of the immune system in children with Down syndrome: a review. Clin Exp Immunol, 2009, 156(2):189-93. doi: 10.1111/j.1365-2249.2009. 03890.x. Epub 2009 Jan 22.

Toscano E, Pacileo G, Limongelli G et al.: Subclinical hypothyroidism and Down’s syndrome; studies on myocardial structure and function. Arch Dis Child, 2003, 88: 1005–1008.

Bull MJ and the Committee on Genetics: Health Supervision for Children with Down syndrome. Pediatrics, 2011, 128; 393; originally published online July 25, 2011.

Gibson PA, Newton RW, Selby K, Price DA, Leyland K, Addison GM: Longitudinal study of thyroid function in Down’s syndrome in the first two decades. Arch Dis Child, 2005, 90:574–578.doi: 10.1136/adc.2004.049536.

Cebeci AN, Güven A, Yıldız M: Profile of Hypothyroidism in Down’s syndrome. J Clin Res Pediatr Endocrinol, 2013, 5(2):116-120.

Oudesluys-Murphy AM, van Wouwe JP and Buitendijk SE: Prevalence of Overweight in Dutch Children with Down syndrome. Pediatrics, 2012, 130(6):e1520-6. doi: 10.1542/peds.2012-0886. Epub 2012 Nov 12.

Ivan DL, Cromwell P: Clinical Practice Guidelines for Management of Children with Down syndrome: Part II. J Pediatr Health Care, 2014, 28:280-284.




DOI: http://dx.doi.org/10.22551/2014.01.0101.10004

Copyright (c)

Creative Commons License
Archive of Clinical Cases is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

ISSN: 2360-6975