Hypofibrinogenemia and miscarriage: report of a first successful pregnancy under fibrinogen substitution and short review of the literature
##plugins.themes.bootstrap3.article.main##
##plugins.themes.bootstrap3.article.sidebar##
Abstract
Abstract
Disorders of fibrinogen have been reported to be associated not only with bleeding and thrombosis but also with miscarriage. Here, we report the case of a woman with genetically determined hypofibrinogenemia and recurrent miscarriages who had a first successful pregnancy under fibrinogen substitution. Current knowledge on fibrinogen disorders and recurrent miscarriages is briefly summarized and discussed.
##plugins.themes.bootstrap3.article.details##
miscarriage, hypofibrinogenemia, fibrinogen substitution
2. Middeldorp S, Naue C, Köhler C. Thrombophilia, Thrombosis and Thromboprophylaxis in Pregnancy: For What and in Whom? Haemostaseologie 2022; 42:54-64.
3. Alijotas-Reig J, Esteve-Valverde E, Anunciación-Llunell A, Marques-Soares J, Pardos-Gea J, Miró-Mur F. Pathogenesis, Diagnosis and Management of Obstetric Antiphospholipid Syndrome: A Comprehensive Review. J Clin Med. 2022; 11:675.
4. Presky KO, Kadir RA. Women with inherited bleeding disorders - Challenges and strategies for improved care. Thromb Res. 2020; 196:569-578.
5. Zhang Y, Zuo X, Teng Y. Women with Congenital Hypofibrinogenemia/ Afibrinogenemia: From Birth to Death. Clin Appl Thromb Hemost. 2020; 26:1076029620912819.
6. Norburn LM. Hypofibrinogenaemia with a 19-weeks abortion. J Obstet Gynaecol Br Emp. 1957; 64:220-221.
7. Rabau E, Szeinberg A. Hypofibrinogenemia in a case of missed abortion. Harefuah. 1957; 52:313-314.
8. Frenkel E, Duksin C, Herman A, Sherman DJ. Congenital hypofibrinogenemia in pregnancy: report of two cases and review of the literature. Obstet Gynecol Surv. 2004; 59: 775-779.
9. Marchi R, López Ramirez Y, Nagaswami C, et al. Haemostatic changes related to fibrin formation and fibrinolysis during the first trimester in normal pregnancy and in recurrent miscarriage. Thromb Haemost. 2007; 97:552-557.
10. Fang J, Xie B, Chen B, et al. Biochemical clinical factors associated with missed abortion independent of maternal age: A retrospective study of 795 cases with missed abortion and 694 cases with normal pregnancy. Medicine (Baltimore). 2018; 97: e13573.
11. Kamimoto Y, Wada H, Ikejiri M, et al. Hypofibrinogenemia and the α-Fibrinogen Thr312Ala Polymorphism may be Risk Factors for Early Pregnancy Loss. Clin Appl Thromb Hemost. 2017; 23: 52-57.
12. Dossenbach-Glaninger A, van Trotsenburg M, Oberkanins C, Atamaniuk J. Risk for early pregnancy loss by factor XIII Val34Leu: the impact of fibrinogen concentration. J Clin Lab Anal. 2013; 27: 444-449.
13. Skotnicki AB, de Moerloose P, Neerman-Arbez M. Severe bleeding and miscarriages in a hypofibrinogenemic woman heterozygous for the gamma Ala82Gly mutation. Blood Coagul Fibrinolysis. 2009; 20: 374-376.
14. McRoyan DK, McRoyan CJ, Kitay DZ, Liu PI. Constitutional hypofibrinogenemia associated with third trimester hemorrhage. Ann Clin Lab Sci. 1986; 16: 52-57.
15. Kaveney AD, Philipp CS. Mild factor XIII deficiency and concurrent hypofibrinogenemia: effect of pregnancy. Blood Coagul Fibrinolysis. 2016; 27: 457-460.
16. Saes JL, Laros-van Gorkom BAP, Coppens M, Schols SEM. Pregnancy outcome in afibrinogenemia: Are we giving enough fibrinogen concentrate? A case series. Res Pract Thromb Haemost. 2020; 4: 343-346.
17. Kobayashi T, Kanayama N, Tokunaga N, Asahina T, Terao T. Prenatal and peripartum management of congenital afibrinogenaemia. Br J Haematol. 2000; 109:364-346.
Archive of Clinical Cases is protected by copyright and may be used in accordance with copyright and other applicable laws. Content available at www.clinicalcases.eu and our digital applications is intended for personal noncommercial use.
Authors who submit a manuscript for publication in Archive of Clinical Cases agree to the following terms: a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) only after the final version of the manuscript was accepted and published, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access). d. It is compulsory that before submission authors ensure that their work was not published in any other medical journals or pending acceptance for publication and that "Archives of Clinical Cases" is the only beneficiary at that moment if their work/case will be accepted by us.
Guidelines for linking to www.clinicalcases.eu a. The main purpose of the site linking to the Archive of Clinical Casess site should be educational. b. Links should be made to the Archive of Clinical Casess home page (www.clinicalcases.eu) or to the articles abstract. c. It is forbidden to use the Archive of Clinical Casess cover by outside organizations unless permission has been granted in advance, notifying our Secretary. d. Material owned by the Archive of Clinical Cases (including the name, logo, cover, and text) may not be used in any manner that may induce the idea or suggest that the Archive of Clinical Cases is in some way recommending a specific company, product or service. e. You must not use or allow others to access or use, all or any part of our Site or the contents and/or applications on it for commercial purposes without our permission. To seek permission to do anything prohibited by or not contained in these TERMS, or which requires our prior consent or agreement, you can contact us.