Ana Maria Calistru Paulo Santos Paulo Morais Filomena Azevedo

Abstract

Digital squamous cell carcinoma is relatively rare and may present a diagnostic challenge by mimicking benign conditions, such as verruca vulgaris. We describe two patients with longstanding verrucous lesions of the nail bed, which proved to be squamous cell carcinoma at the histopathology examination, with molecular and cytological evidence of HPV infection. Complete excision was performed. The cases highlight the necessity of a high index of suspicion in longstanding verrucous lesions of the digits, resistant to conventional anti-verruca vulgaris treatments.

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Keywords

squamous cell carcinoma, nail bed, HPV

References
1. Riddel C, Rashid R, Thomas V: Ungual and periungual human papillomavirus-associated squamous cell carcinoma: A review. J Am Acad Dermatol, 2011, 64(6):1147-53.
2. Hunt R, Hwa C, Tzu J, Patel R, Tyring SK, Stein J: Multiple human papillomavirus 16 associated digital squamous-cell carcinomas in an immunocompetent woman with prior human papillomavirus related genital carcinoma. Dermatol Online J, 2011, 17(10):20.
3. Kreuter A, Gambichler T, Pfister H, Wieland U: Diversity of human papillomavirus types in periungual squamous cell carcinoma. Br J Dermatol, 2009, 161(6):1262-9.
4. Alam M, Caldwell JB, Eliezri YD: Human papillomavirus-associated digital squamous cell carcinoma: literature review and report of 21 new cases. J Am Acad Dermatol, 2003, 48(3):385-93.
How to Cite
Calistru, A. M., Santos, P., Morais, P., & Azevedo, F. (2014). Verrucous carcinoma of the nail bed in two patients with evidence of Human Papillomavirus infection. Archive of Clinical Cases, 1(1), Arch Clin Cases 2014; 1(1):1-3. https://doi.org/10.22551/2014.01.0101.10001
Section
Case Reports

How to Cite

Calistru, A. M., Santos, P., Morais, P., & Azevedo, F. (2014). Verrucous carcinoma of the nail bed in two patients with evidence of Human Papillomavirus infection. Archive of Clinical Cases, 1(1), Arch Clin Cases 2014; 1(1):1-3. https://doi.org/10.22551/2014.01.0101.10001