Aurélie Phulpin-Weibel Ludovic Mansuy Valérie Bernier-Chastagner Marie-Agnès Galloy Pierre Bordigoni Pascal Chastagner

Abstract

We report the case of a very high risk metastatic rhabdomyosarcoma teenager treated with an induction therapy using only liposomal doxorubicin (Myocet®) because of his extremely bad health condition. A near complete remission was obtained after 2 courses. Then he received conventional chemotherapy according to the EpSSG protocol, radiotherapy and a reduced-intensity conditioning regimen followed by pheno-identical allogeneic stem cell transplantation. He is in continuous complete remission with a follow-up of nine years.

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Keywords

metastatic rhabdomyosarcoma, liposomal anthracycline

References
1. Breneman JC, Lyden E, Pappo AS, et al. Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study IV. J Clin Oncol 2003; 21:78-84.
2. Oberlin O, Rey A, Lyden E, et al. Prognostic factors in metastatic rhabdomyosarcomas: results of a pooled analysis from United States and European cooperative groups. J Clin Oncol 2008; 26:2384-2389.
3. Bergeron C, Thiesse P, Rey A, et al. Revisiting the role of doxorubicin in the treatment of rhabdomyosarcoma: an up-front window study in newly diagnosed children with high-risk metastatic disease. Eur J Cancer 2008; 44:427-431.
4. Marina NM, Cochrane D, Harney E, et al. Dose escalation and pharmacokinetics of pegylated liposomal doxorubicin (Doxil) in children with solid tumors: a pediatric oncology group study. Clin Cancer Res 2002; 8:413-418.
5. Stavridi F, Palmieri C. Efficacy and toxicity of nonpegylated liposomal doxorubicin in breast cancer. Expert Rev Anticancer Ther 2008; 8:1859-1869.
6. Bisogno G, Ferrari A, Bergeron C, et al. The IVADo regimen-a pilot study with ifosfamide, vincristine, actinomycin D, and doxorubicin in children with metastatic soft tissue sarcoma: a pilot study of behalf of the European pediatric Soft tissue sarcoma Study Group. Cancer 2005; 103:1719-1724.
7. Childs R, Chernoff A, Contentin N, et al. Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med 2000; 343:750-758.
8. Chan KW, Rogers PC, Fryer CJ. Breast metastases after bone marrow transplantation for rhabdomyosarcoma. Bone Marrow Transplant 1991; 7:171-172.
9. Misawa A, Hosoi H, Tsuchiya K, et al. Regression of refractory rhabdomyosarcoma after allogeneic stem-cell transplantation. Pediatr Hematol Oncol 2003; 20:151-155.
10. Doelken R, Weigel S, Schueler F, et al. Poor outcome of two children with relapsed stage IV alveolar rhabdomyosarcoma after allogeneic stem cell transplantation. Pediatr Hematol Oncol 2005; 22:699-703.
11. Donker AE, Hoogerbrugge PM, Mavinkurve-Groothuis AM, et al. Metastatic rhabdomyosarcoma cured after chemotherapy and allogeneic SCT. Bone Marrow Transplant 2009; 43:179-180.
12. Koscielniak E, Klingebiel TH, Peters C, et al. Do patients with metastatic and recurrent rhabdomyosarcoma benefit from high-dose therapy with hematopoietic rescue? Report of the German/ Austrian Pediatric Bone Marrow Transplantation Group. Bone Marrow Transplant 1997; 19:227-231.
13. Ohta H, Hashii Y, Yoshida H, et al. Allogeneic hematopoietic stem cell transplantation against recurrent rhabdomyosarcoma. J Pediatr Hematol Oncol 2011; 33:e35-38.
How to Cite
Phulpin-Weibel, A., Mansuy, L., Bernier-Chastagner, V., Galloy, M.-A., Bordigoni, P., & Chastagner, P. (2014). Complete remission of a high risk metastatic rhabdomyosarcoma in an adolescent treated with a liposomal (Myocet®) regimen. Archive of Clinical Cases, 1(2), Arch Clin Cases 2014; 1(2):52-55. https://doi.org/10.22551/2014.02.0102.10012
Section
Case Reports

How to Cite

Phulpin-Weibel, A., Mansuy, L., Bernier-Chastagner, V., Galloy, M.-A., Bordigoni, P., & Chastagner, P. (2014). Complete remission of a high risk metastatic rhabdomyosarcoma in an adolescent treated with a liposomal (Myocet®) regimen. Archive of Clinical Cases, 1(2), Arch Clin Cases 2014; 1(2):52-55. https://doi.org/10.22551/2014.02.0102.10012