The cardiac electrical status of a patient with a mithocondrially inherited disease - case report

Delia Nebunu, Juan Antonio Sieira Rodríguez-Moret, Rubén Casado-Arroyo

Abstract


Cardiac complications, such as myocardial disease and arrhythmias, are frequent and may be severe in patients with mitochondrial disease. Mitochondrial diseases are a heterogeneous group of disorders that can affect multiple organs with varying severity. We hereby present the case of a 58-year-old man admitted in the Cardiology Department for an Electrophysiological study asked by his General practitioner in the context of a past medical history evident for a mitochondrial cytopathy and subsequent to arrhythmic symptomatology revealed as uncomfortable palpitations and to disclosure of Holter bursts of supraventricular tachycardia.

Keywords


supraventricular tachycardia, electrophysiological study, ablation, Leber disease

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References


Nikoskelainen E, Wanne O, Dahl M. Pre-excitation syndrome and Leber's hereditary optic neuroretinopathy. Lancet 1985; 1(8430):696.

Man PY, Turnbull DM, Chinnery PF. Leber hereditary optic neuropathy. J Med Genet 2002; 39:162–9.

Bernier FP, Boneh A, Dennett X. Diagnostic criteria for respiratory chain disorders in adults and children. Neurology 2002; 59:1406-1411.

Wahbi K, Larue S, Jardel C, et al. Cardiac involvement is frequent in patients with the m.8344A>G mutation of mitochondrial DNA. Neurology 2010; 74:674-677.

Harding AE, Sweeney MG, Govan GG, Riordan-Eva P. Pedigree analysis in Leber hereditary optic neuropathy families with a pathogenic mtDNA mutation. Am J Hum Genet 1995; 57:77-86.

Biousse V, Brown MD, Newman NJ, et al. De novo 14484 mitochondrial DNA mutation in monozygotic twins discordant for Leber's hereditary optic neuropathy. Neurology 1997; 49:1136–8.

Robert M, Zipes D. Mechanisms of arrhythmogenesis. In Bonow RO, Mann DL, Zipes D, Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 9th Edition, Philadelphia: Elsevier Saunders 2012; 672-678.




DOI: http://dx.doi.org/10.22551/2014.02.0102.10011

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